| 名稱 | CDKN2A p.ATAAA17fs Reference Standard 標(biāo)準(zhǔn)品 |
| 型號 | CBP10434 |
| 報(bào)價(jià) |  |
| 特點(diǎn) | CDKN2A p.ATAAA17fs Reference Standard |
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電話：4008750250
號碼：
手機(jī)：18066071954
地址：南京市棲霞區(qū)緯地路9號
Email： zhangxiangwen@cobioer.com
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基因檢測標(biāo)準(zhǔn)品 > Mutation > CBP10434CDKN2A p.ATAAA17fs Reference Standard 標(biāo)準(zhǔn)品
- 詳細(xì)內(nèi)容
CBP10434 | |
| Gene | CDKN2A |
| Description | CDKN2A, cyclin-dependent kinase inhibitor 2A, is a tumor suppressor (PMID: 30562755) that encodes p16 and p14ARF from alternate reading frames, which function to inhibit Cdk4 and Cdk6 and regulate Tp53 activity to promote cell-cycle arrest (PMID: 23875803, PMID: 17055429, PMID: 27428416). CDKN2A germline mutations are associated with familial atypical multiple mole melanoma and somatic mutations are highest in pancreatic, HNSCC, NSCLC, and melanoma (PMID: 27283171). |
| Technical Data | |
| DNA Change | c.37_49del |
| AA Change | p.ATAAA17f |
| Mutation type | Frame_Shift_Del |
| Zygosity | Heterozygous |
| Allelic Frequency | 50.00% |
| Transcript | ENST00000304494.5 |
| Cosmic ID | N/A |
| Chr position(GRCh37) | chr9:21974790_21974778 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |
|
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
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