| 名稱 | PIK3CA p.H1047L Reference Standard 標(biāo)準(zhǔn)品 |
| 型號 | CBP10320 |
| 報價 |  |
| 特點(diǎn) | PIK3CA p.H1047L Reference Standard |
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基因檢測標(biāo)準(zhǔn)品 > Mutation > CBP10320PIK3CA p.H1047L Reference Standard 標(biāo)準(zhǔn)品
- 詳細(xì)內(nèi)容
CBP10320 | |
| Format | Genomic DNA |
| Description | PIK3CA H1047L is a hotspot mutation that lies within the PI3K/PI4K domain of the Pik3ca protein (UniProt.org). H1047L confers a gain of function on the Pik3ca protein as indicated by increased phosphorylation of Akt and Mek1/2, growth factor-independent cell survival, and transformation in cell culture (PMID: 26627007, PMID: 29533785). |
| Technical Data | |
| DNA Change | c.3140A>T |
| AA Change | p.H1047L |
| Mutation type | Substitution - Missense |
| Zygosity | Heterozygous |
| Allelic Frequency | 50% |
| Transcript | NM_006218.1 |
| Cosmic ID | COSM776 |
| Chr position(GRCh37) | chr3:178952085 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |
|
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
