名稱 | TP53 p.P278S Reference Standard 標(biāo)準(zhǔn)品 |
型號 | CBP10200 |
報(bào)價(jià) | ![]() |
特點(diǎn) | TP53 p.P278S Reference Standard |
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基因檢測標(biāo)準(zhǔn)品 > Mutation > CBP10200TP53 p.P278S Reference Standard 標(biāo)準(zhǔn)品

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CBP10200 | |
Format | Genomic DNA |
Description | TP53 P278S lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). P278S results in the loss of Tp53 transactivation of p21, while retaining activation of Axl in cell culture, and promotes tumor growth in xenograft models (PMID: 22989750), and in mouse cells harboring the equivalent mouse variant (P275S), results in decreased activation of Tp53 target genes and reduced apoptotic response following DNA damage (PMID: 11867759). |
Technical Data | |
DNA Change | c.832C>T |
AA Change | p.P278S |
Mutation type | Substitution - Missense |
Zygosity | Homozygous |
Allelic Frequency | 100% |
Transcript | ENST00000269305 |
Cosmic ID | COSM10939 |
Chr position(GRCh37) | chr17:7577106 |
Buffer | Tris-EDTA |
Product Information | |
Intended Use | Research Use Only |
Unit Size | 1ug |
Concentration | Download for COA |
Purofication | Download for COA |
DNA electrophoresis | Download for COA |
Sanger sequencing | Download for COA |
Storage | 4℃ |
Expiry | 36 months from the date of manufacture |