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藥靶細(xì)胞株 > GPCR細(xì)胞株 > CBP71367mADORA2B/CHO GPCR細(xì)胞

mADORA2B/CHO GPCR細(xì)胞
名稱(chēng) mADORA2B/CHO GPCR細(xì)胞
型號(hào) CBP71367
報(bào)價(jià)
特點(diǎn) mADORA2B/CHO
  • 詳細(xì)內(nèi)容
CBP71367                
I. Background                

The adenosine receptors ADORA2B is Gs and Gq/G11-coupled GPCR expressed in the large intestine, cecum, and urinary bladder. ADORA2B receptor mediates relaxation to adenosine in human small coronary arteries which is independent of NO but dependents in part on a K+-sensitive mechanism. Pharmacological or molecular biologic activation of ADORA2B receptor may prevent glomerular remodeling associated with glomerulosclerosis, renal disease, and abnormal growth associated with hypertension and diabetes.                    


II. Introduction                
Host Cell:                

CHO                    

Stability:                20 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)                
Freeze Medium:                90% FBS+10% DMSO                
Culture Medium:                N/A                
Mycoplasma Status:                Negative                
Storage:                Liquid nitrogen immediately upon delivery                
Application(s):                

Functional assay for mADORA2B receptor                    

Transducer:                Gs                

Ⅲ. Description of Host Cell Line                
Organism:                Hamster                
Tissue:                Ovary                
Morphology:                Epithelial                
Growth Properties:                Adherent                

Ⅳ. Representative Data                


                   

CBP71367.png                    


Figure 1. NECA efffect on CHO-K1-mA2B-clone 6.                    



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